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Components of the InsR pathway, including age-1, have recently been predicted to be targets of miR-71 in its role in aging (14). On the other hand, the role of a particular miRNA (miR-71) is executed by repressing the expression of many genes in multiple pathways. These results compelled us to examine specific interactions between individual miRNAs and their targets to gain mechanistic insights. This result is also consistent with the prediction from a miRISC immunoprecipitation analysis that hbl-1 is likely a target of one or more miRNAs, in addition to the let-7 family miRNAs, during early development (18). This result suggests that miR-71 likely functions upstream of, or in parallel to, HBL-1 in regulating VPC timing.
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- This is consistent with hbl-1 being one of the downstream targets of miR-71, although this modest effect alone is not expected to account for the vulval developmental phenotype in mir-71 mutant.
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- (Right panels) The gonad of the same animals in the Left panels to indicate the similar developmental stage.
- We identified a conserved “pause and play” mechanism of cell cycle during environmental stress and recovery.
